Endocrine Abstracts

Background and aims: Neuropeptide Y (NPY) cause decrease glomerular filtration rate, aldosterone concentration, and plasma renin activity by stimulating NPY receptors in the kidney. Previous studies have suggested that NPY polymorphism is related to development of advanced diabetic nephropathy (DN). The aim of this study was to evaluate the relationship between the serum neuropeptide Y levels and different stages of DN in patients with type 2 diabetes mellitus (T2DM).<p cl...

Background and aims: Orexins are hypothalamic neuropeptides involved in energy homeostasis and sleep regulation. We aimed to find the relation between serum orexin-A levels, glucose, and insulin levels, depression and sleep problems in patients with metabolic syndrome.Materials and methods: This descriptive, cross-sectional study included 43 patients with metabolic syndrome (patient) and 16 healthy subjects (control, age, and sex matched) who applied to ...

Introduction: Polycystic ovary syndrome (PCOS) is widely diagnosed among young women in reproductive age. Vitamin D deficiency has been known as a common problem in all ages and also in a recent study which performed in a small study groups, reported that it may accompany with hyperandrogenism. The aim of our study is to evaluate serum 25(OH)D3 levels in PCOS patients compared with healthy control and relation to androgen levels.Methods: Forty...

Background and aims: Hypovitaminosis D may be associated with metabolic parameters in addition to its well-known calcemic actions. There is increasing evidence that vitamin D metabolism affects the risk of insulin resistance although the underlying molecular mechanism of this association is not clear but on the basis of evidence it is not clear whether or not vitamin D supplementation therapy in vitamin D-deficient prediabetics affects the prevention of type 2 diabetes. Our st...

Objective: Recent recommendations suggest that HbA1c as a stable and standardised index of chronic glucose exposure over time and could be used as a better biochemical marker for the diagnosis of diabetes and prediabetes. Our aim in this cross-sectional study is to assess the validity of HbA1c as a screening tool for the detection of prediabetes in our patient population.Methods: The study was done in 265 patients selected among the participants attended...

Objective: Thyroid hemiagenesis is a rare form of thyroid dysgenesis, in which one thyroid lobe fails to develop. The true prevalence of this rare abnormality is about 0.05–0.2% in normal population. We aimed to determine prevalence of thyroid hemiagenesis in patients with various thyroid disorders and a normal population in a mild to moderate iodine-deficient area.Subjects and methods: The clinical and thyroid ultrasonography records of 4.833 patie...

In this study we compared plasma adiponectin levels between patients with non-functional adrenal incidentaloma and subclinical Cushing’s syndrome. Our aims were to determine whether there was any difference of plasma adiponectin levels, any relation between cardiovasculer risk factors and to investigate the importance of adiponectin levels in subclinical Cushing’s syndrome patients according to non-functional adrenal incidentaloma patients. The patients referred from...

Objective: Low skeletal muscle mass is an emerging risk factor for metabolic disorders. In this study, we aimed to evaluate the relationships between fat mass, muscle mass, muscle fat mass ratio, total fat mass, and abdominal fat mass ratio by comparing the body compositions in obese women with and without metabolic syndrome.Methods: Totally 89 obese women (mean±S.D., age 42.1±12 years, BMI 36.5±4.2%) with newly diagnosed me...

Background: Bullous pemphigoid is an autoimmune blistering disease that commonly arise in elderly with increased risk for mortality and morbidity. The aetiology of this disease is not entirely clear, although a few cases have been described with dipeptidyl peptidase IV inhibitors.Case 1: A 81-year-old man presented with bullous pemphigoid after 28-month treatment with repaglinide, vildagliptin, and metformin. The patient’s condition didn’t impr...

Introduction: The total energy expenditure in pregnancy is increased largely due to elevated basal metabolic rate (BMR) during pregnancy. The aim of this study is to evaluate the effects of gestational diabetes on basal metabolic rate, body weight and HbAlc, by comparing these parameters in gestational diabetic and healthy pregnant women.Method: Fifty-eight gestational diabetic women (GDM) and fourty healthy non diabetic pregnants who had normal thyroid ...